Advancements in Extrusion-Spheronization. More agile techniques are improving the development of multiparticulate drug-delivery systems. Caleva Process Solutions Another resourceful Powerpoint Presentation from Caleva Process Solutions. These selection. Extrusion – to form rod shaped particles of uniform diameter. Spheronization – to round off these rods into spherical particles. Drying – to.
|Published (Last):||25 February 2004|
|PDF File Size:||17.84 Mb|
|ePub File Size:||2.65 Mb|
|Price:||Free* [*Free Regsitration Required]|
Extrusion & Spheronization Pharmaceutical Technology
Application of Multiparticulate Technologies for Drug Delivery. The technology chosen is dependent upon multiple active ingredient and formulation criteria, e. Common applications include annd release, extended release, pulsatile release, and fixed dose combinations.
This dough then pressed through an extruder. Please read our updated Cookies Policy for information about which cookies we use and the information we collect. Moistening the powder mixture, forming cylinder-shaped agglomerate through extrusion, breaking and rounding the extrudate to round pellets through spheronization, and drying the finished product. The process consists of five operations. The resultant spheres are dried in a fluid bed dryer and particle size is selected by sieve cuts.
The wet mass is added into an LCI Multigranulator MG 55 where it is forced through a specific screen to form cylindrical extrudates using either dome, radial or axial extrusion for process optimization.
You can disable cookies but parts of our website may not work. It is useful for making dense granules for controlled-release extrision oral dosage forms with a minimum amount of excipients, as well as multiparticulates used for immediate, modified, sspheronization sustained-release.
Capsugel has extensive experience and capabilities in optimizing pediatric sphernoization multiparticulate formulations. In other industries, the size of the pellets can be several centimeters.
Extrusion / Spheronization
By continuing to use this website, you agree that we may store and access cookies on your device. Even if the ball-shaped extrudate is imperfect, the evenness of the surface still creates good conditions spheronizatino subsequent coating. In the pharmaceutical industry, pellets of medium particle sizes from to 2, micrometers are used for most applications.
By Product Development Site. Register for An Account Already a member?
The spheres may undergo additional processing steps to apply functional or cosmetic coatings using fluid bed processing with a Wurster insert. Capsugel has extensive experience in designing, formulating and scaling mulitparticulate dosage forms at feasibility, pilot and commercial scales. Capsugel offers a drug delivery technology to provide oral delivery with full enteric protection and rapid release in the upper gastrointestinal GI tract without the use of coatings.
The ratio of liquid to solid material together with the size of the extruder holes significantly determines the quality of the extrudates.
For technical reasons, the resulting pellets are larger than micrometers. The wet extrudate is added to an LCI Marumerizer QJT spheronizer equipped with a high speed spinning plate which forms uniform spheres from the extrudate “rope”. Cookies allow us to give you the best browsing experience and help us to understand how you use our site. The process consists of four process steps: Agglomeration through extrusion and spheronization is one of the oldest techniques for manufacturing pellets.
For many pharmaceutical applications, extruded pellets are achieved in suitable quality if a sufficient portion of microcrystalline cellulose is added.
Overview of the Extrusion-Spheronization Process
Join us for the multiparticulates webinar, where key considerations in designing multiparticulate formulations and processing will be discussed with representative case studies.
The dry, mixed, powdery active substances are kneaded into a dough with a liquid.